CHRONIC PAIN
Positive self belief key to recovery from shoulder pain: Positive self belief is the
key to recovery from pain, say Uresearchers. The research team studied over
1,000 people undergoing physiotherapy for shoulder pain. They found that people
are more likely to recover if they have the confidence to carry on doing most
things, despite their pain. Those who expected physiotherapy would help them
were likely to recover more than those who expected minimal or no benefit. British
Journal of Sports Medicine,
Higher Optimism Tied to Lower Odds of Pain After Deployment: For U.S.
soldiers, higher levels of optimism are associated with lower odds of reporting
new pain after deployment, according to a study published online Feb. 8 in JAMA
Network Open.
Certain Opioids Less Effective With SSRI Antidepressants: Certain opioids are less effective for postoperative
pain in patients taking selective serotonin reuptake inhibitor (SSRI)
antidepressants, according to a study published online Feb. 6 in PLOS ONE.
Discord Found in Clinician-, Criteria-Based Fibromyalgia Diagnosis: There is
disagreement between clinical diagnosis and criteria-based diagnosis of
fibromyalgia, according to a study published online Feb. 6 in Arthritis Care
& Research. Physicians fail to ID half of criteria-positive patients,
incorrectly ID 11 percent of criteria-negative patients. "It is likely
that misdiagnosis is a public health problem and one that can lead to
over diagnosis and over treatment, as well as to inappropriate treatment of
individuals not recognized to have fibromyalgia symptoms.”
Compounded Topical Pain Creams No Better Than Placebo: Compounded
topical pain creams are no better than placebo creams for neuropathic pain,
nociceptive pain, or mixed pain, according to a study published online Feb. 5
in the Annals of Internal Medicine.
Evidence Lacking for Benefit of Surgery for Vertebral Fractures: Surgical
procedures do not appear to provide significant benefit for patients with
vertebral fractures (VF), according to a second American Society for Bone and
Mineral Research Task Force report published in the January issue of the Journal
of Bone and Mineral Research.
COMPLEMENTARY &
ALTERNATIVE MEDICINE
Evidence of Therapeutic Efficacy Substantial for Cannabis Use: Most qualifying
conditions for which patients are licensed to use cannabis medically have
substantial or conclusive evidence of therapeutic efficacy, according to a
report published in the February issue of Health Affairs.
Mindfulness-Based Stress Reduction Also Benefits Chronic Pain: For
patients with chronic pain (CP), both mindfulness-based stress reduction (MBSR)
and cognitive behavioral therapy (CBT) improve physical functioning, pain
intensity, and depression, according to a review published online Jan. 31 in Evidence-Based
Mental Health.
Medical Cannabis Decisions Being Made by Users, Not Doctors: Many
patients use medical cannabis without their mainstream health care provider's
knowledge, and further, they self-adjust their pharmaceutical use in response
to cannabis use, according to a study published online Jan. 8 in the Journal
of Psychoactive Drugs.
Yoga
regimen reduces severity of rheumatoid arthritis symptoms: According
to a new study, eight weeks of intensive yoga practice significantly decreases
the severity of physical and psychological symptoms in patients with active rheumatoid
arthritis (RA), a debilitating chronic auto-immune inflammatory disease. Marked
improvements were seen in the levels of certain inflammatory biomarkers and
assessments of functional status and disease activity in patients studied,
demonstrating yoga's promotive, preventive, curative, and rehabilitative
potential for achieving optimal health.
Restorative Neurology and Neuroscience
FDA ACTION
• Issued Statement from FDA
Commissioner Scott Gottlieb, M.D., on new policy to improve access and foster
price competition for drugs that face inadequate generic competition
• Authorizes first
interoperable insulin pump intended to allow patients to customize treatment
through their individual diabetes management devices
• Issued statement from FDA
Commissioner Scott Gottlieb, M.D., on the agency’s new efforts to strengthen
regulation of dietary supplements by modernizing and reforming FDA’s oversight
• Takes action against
17 companies for illegally selling products claiming to treat Alzheimer’s
disease
• Approved
Cablivi (caplacizumab-yhdp) injection, the first therapy specifically
indicated, in combination with plasma exchange and immunosuppressive therapy,
for the treatment of adult patients with acquired thrombotic thrombocytopenic
purpura (aTTP), a rare and life-threatening disorder that causes blood
clotting.
•
Warned patients and doctors, who use at-home or in-the-office medical devices
to monitor levels of the blood thinner warfarin, that certain test strips used
with the devices may provide inaccurate results and should not be relied upon
to adjust the drug dosage. Medical product distributor Terrific Care/Medex Supply
LLC issued a voluntary Recall of certain Roche Diagnostic test lots used with
CoaguCheck test meter devices.
• Approved
the first generic of Advair Diskus (fluticasone propionate and salmeterol
inhalation powder) for the twice-daily treatment of asthma in patients aged
four years and older
•
Permitted marketing of a new test to aid in the diagnosis of a
sexually-transmitted infection (STI) called Mycoplasma
genitalium (M. gen.).
• Approved
the first generic version of Sabril (vigabatrin) 500 mg tablets for treating
complex partial seizures, also called focal seizures, as an adjunctive therapy
(given with another primary treatment) in patients 10 years and older who have
responded inadequately to several alternative (refractory) treatments.
PREVENTION
How exercise may protect against Alzheimer's: A hormone called irisin -- produced during exercise
-- may protect neurons against Alzheimer's disease. Nature Medicine
Aerobic Exercise Tied to Better Cognition at All Ages: Aerobic exercise contributes to brain health in
individuals as young as 20 years, according to a study published online Jan. 30
in Neurology. The researchers found that aerobic capacity increased
significantly and body mass index decreased significantly in the aerobic
exercise group but not in the stretching/toning group. In the aerobic exercise
group, executive function improved significantly, with the effect moderated by
age. The aerobic exercise group had significant increases in cortical thickness
in a left frontal region, with no interaction with age.
How sleep can fight infection: Researchers have discovered why sleep can sometimes
be the best medicine. Sleep improves the potential ability of some of the
body's immune cells to attach to their targets, according to a new study. The
study helps explain how sleep can fight off an infection, whereas other
conditions, such as chronic stress, can make the body more susceptible to
illness. Journal of Experimental Medicine
Accelerated risk of mobility loss for people aged 60+
tied to excess weight/inactivity:New study shows older women with obesity at higher risk of mobility loss
compared to older men. The combination of excess weight/obesity and an inactive
lifestyle represents a powerful joint risk factor for developing mobility loss
after age 60, according to a new study. International Journal of Obesity.
Fewer Older Men Assessed, Treated for Osteoporosis: Fewer older men than women undergo evaluation for or
management of osteoporosis, according to a study published online Feb. 12 in
the Journal of Investigative Medicine.
Most A-Fib Patients Have at Least One Identifiable
Trigger: Most patients with atrial
fibrillation (AF) report at least one identifiable trigger, with the most
common triggers being alcohol, caffeine, exercise, and lack of sleep, according
to research published online Feb. 14 in HeartRhythm.
CDC Examines Safety of Recombinant Zoster Vaccine: During the first eight months of recombinant zoster
vaccine (RZV) use, there were reports of 4,381 adverse events, 3 percent of
which were serious, according to research published in the Feb. 1 issue of the
U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly
Report.
E-Cigarettes More Effective for Smoking Cessation: Electronic cigarettes are more effective for smoking
cessation than nicotine replacement therapy, according to a study published
online Jan. 30 in the New England Journal of Medicine.
New Type of E Cigarette as Bad as Regular: “Heat-not-burn” tobacco products are already incredibly
popular in some overseas markets, but they haven’t made inroads into the United
States yet. Promoted in a similar fashion to e-cigarettes as a safer
alternative to traditional smoking, public health experts worry that
“heat-not-burn” products could be the next big phase for the tobacco industry.
New research looked at the in vitro effects of vapor produced by IQOS devices
(IQOS is the brand name of a “heat-not-burn” tobacco product by Philip Morris
International, an American tobacco company) on human cells found in the lungs
and airways. IQOS device’s vapor was found to have a comparable toxicity to
traditional smoking. ERJ Open Research
Trained Alert Dogs Can Detect Impending T1DM-Related Events: Trained alert dogs can help
patients with type 1 diabetes regulate their blood glucose levels, according to
a study published online Jan. 15 in PLOS ONE.
NUTRITION/SUPPLEMENTS/VITAMINS
Higher sodium intake associated with increased
light headedness in the context of the DASH-sodium trial: Study turns common knowledge on its head by
challenging experts' traditional recommendations Researchers found that higher
sodium intake, when studied in the context of the DASH-Sodium trial (Dietary
Approaches to Stop Hypertension), increases lightheadedness. These findings
challenge traditional recommendations to increase sodium intake to prevent
lightheadedness. The Journal of Clinical Hypertension
Fried Chicken, Fish Linked to All-Cause,Cardiovascular Death: Among
postmenopausal women, fried food consumption, especially fried chicken and
fish/shellfish, is associated with an increased risk for all-cause and
cardiovascular mortality, according to a study published online Jan. 23 in The
BMJ.
Body building supplement could be bad for the brain: L-norvaline is an ingredient widely used in body
building supplements and is promoted as a compound that can boost workouts and
aid recovery. Similar compounds have been linked to neurodegenerative diseases,
and a study on human cells suggests L-norvaline may also cause damage to brain
cells. People taking the protein supplement L-norvaline should be aware of its
potential for harm, scientists say. Toxicology in Vitro
Bone Health in Older Adults Not Improved by High-Dose Vitamin D: There is little benefit
for older adults taking high-dose vitamin D supplements to improve their bone
strength and reduce the risk for falls, according to a study published online
Jan. 8 in The American Journal of Clinical Nutrition.
Study examines aspirin use to prevent colorectal
cancer: The US Preventive Services
Task Force (USPSTF) concluded that aspirin reduces the risk of colorectal
cancer by 40 percent as well as recurrence of advanced polyps, which are a
major risk factor. To explore whether high risk patients are adhering to USPSTF
guidelines, researchers analyzed data from structured interviews with 84
patients and found that less than half (42.9 percent) reported taking aspirin.
These findings pose major challenges that require multifactorial approaches by
physicians and patients. The American
Journal of Medicine
Meta-Analysis: Aspirin Linked to Lower Risk for CV Events in Primary Prevention: For
individuals without cardiovascular disease, use of aspirin is associated with a
reduced risk for cardiovascular events and an increased risk for major
bleeding, according to a meta-analysis published in the Jan. 22 issue of the
Journal of the American Medical Association.
Artificially Sweetened Drinks Linked to Stroke After Menopause: Among postmenopausal
women, consumption of artificially sweetened beverages (ASB) is associated with
an increased risk for stroke, coronary heart disease, and all-cause mortality,
according to a study published online Feb. 14 in Stroke.
TREATMENT
Direct-acting antivirals reduce risk of premature mortality and liver cancer for people with chronic hepatitis C, study finds: The first prospective, longitudinal study
investigating treatment of chronic hepatitis C with direct-acting antivirals
finds that the treatment is associated with reduced risk of mortality and liver
cancer. The Lancet
Shorter course of radiation therapy effective in treating men with prostate cancer: A
long-term study finds that those with low- or intermediate-risk disease can
safely cut treatment to four to five days.
This type of radiation, known as stereotactic body radiotherapy, is a
form of external beam radiation therapy and reduces the duration of treatment
from 45 days to four to five days. The approach has been in use since 2000, but
has not yet been widely adopted because of concerns over how safe and effective
this approach would be in the long term. JAMA
Study links psoriasis treatment and improvement in heart artery disease: Researchers
have found that treating psoriasis, a chronic inflammatory skin disease, with
biologic drugs that target immune system activity can reduce the early plaque
buildup that clogs arteries, restricts blood flow, and leads to heart attacks
and stroke. The findings highlight how immunotherapies that treat inflammatory
conditions might play a role in the reduction of cardiovascular disease risks.
Cardiovascular Research
Subsymptom Threshold Exercise Speeds Concussion Recovery: For adolescent athletes,
subsymptom threshold aerobic exercise prescribed during the first week after
sport-related concussion (SRC) speeds recovery, according to a study published
online Feb. 4 in JAMA Pediatrics.
Trazodone Not Associated With Reduced Risk for Dementia: Trazodone is not
associated with a reduced risk for dementia compared with other antidepressants
at the prodromal stage of disease, according to a study published online Feb. 5
in PLOS Medicine.
Intensive BP Treatment Does Not Reduce Dementia Risk: Treating systolic blood pressure (BP) to a goal of
less than 120 mm Hg rather than 140 mm Hg does not result in a significant
reduction in the risk for probable dementia, according to a study published
online Jan. 28 in the Journal of the American Medical Association.
NOACs Recommended as First-Line Prevention of Stroke in A-Fib: For patients with atrial
fibrillation, novel oral anticoagulants (NOACs) are recommended over warfarin
to prevent stroke and weight loss is recommended for overweight and obese
individuals, according to updated guidelines published online Jan. 28 in
Circulation.
OTHER
New scan technique reveals brain inflammation associated with post-treatment Lyme disease syndrome: More than 1 in 10 people successfully treated with
antibiotics for Lyme disease go on to develop chronic, sometimes debilitating,
and poorly understood symptoms of fatigue and brain fog that may last for years
after their initial infection has cleared up. Now, in a small study, Johns Hopkins
Medicine researchers report they have used an advanced form of brain scan to
show that 12 people with documented post-treatment Lyme disease syndrome
(PTLDS) all show elevation of a chemical marker of widespread brain
inflammation, compared with 19 healthy controls. Journal of Neuroinflammation
Health Care Spending Per Person Increased to $5,641
in 2017: In 2017, health care
spending per person reached $5,641, according to the Health Care Cost Institute
(HCCI) annual Health Care Cost and Utilization Report.
USPSTF Still Recommends Against Pancreatic Cancer
Screening: The U.S. Preventive
Services Task Force (USPSTF) recommends against screening for pancreatic cancer
in asymptomatic adults. These findings form the basis of a draft recommendation
statement published online Feb. 5 by the USPSTF.
AHA: Nearly Half of U.S. Adults Have Cardiovascular
Disease: The prevalence of
cardiovascular disease (CVD) is 48.0 percent in adults in the United States
based on 2013 to 2016 data, according to a report published online Jan. 31 in
Circulation. Forty-six percent of U.S. adults have hypertension
Large Insulin Price Hike to Be Investigated by U.S.
Congress: "I have heard stories
about people reducing their lifesaving medicines, like insulin, to save
money," said Senate Finance Committee Chairman Charles Grassley, R-Iowa,
the Associated Press reported. "This is unacceptable and I intend to
specifically get to the bottom of the insulin price increase."
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