Saturday, June 20, 2026

Journal Watch June 2026


                                                                         PAIN

Pain supplement glucosamine linked to faster dementia progression: Οne popular supplement for osteoarthritis is glucosamine sulfateTrusted Source, which people take to alleviate pain and stiffness. According to one study, around 6-7% of people over the age of 70 in the United States are prescribed glucosamine to relieve symptoms. Many more buy it without prescription as a dietary supplement, despite there being little study evidenceTrusted Source for its efficacy. Now, a new study has found that glucosamine may speed the progression of dementia and hasten mortality, by enhancing a process in the brain that is overactive in people with Alzheimer’s disease. The study, which is published in Nature MetabolismTrusted Source, suggests that glucosamine may increase hyperglycosylation — a process that impairs the function of nerve cells in the brain.

 

Common dizziness drug class shows promise for treating vestibular migraine: A new study finds that a class of oral and intranasal medications known as gepants may be an effective and well-tolerated treatment for vestibular migraine (VM). Otolaryngology

 

At least two weather patterns increase headaches, University of Cincinnati study suggests: Two specific weather patterns were associated with a higher risk of new-onset headaches in the Northeastern region. One is an approaching cold front, or low-pressure system, with precipitation, which can occur in all seasons. The other is the Bermuda High, a high-pressure system that heavily dictates summer weather across the eastern half of the U.S.  American Headache Society Annual Scientific Meeting

 

GLP-1 agonists linked to significantly lower long term risk of knee replacement: GLP-1 receptor agonist drugs, used for the treatment of diabetes, and more recently, weight loss, are associated with a significantly lower long term risk of knee replacement surgery as a result of osteoarthritis, finds an analysis of medical records data, published in the open access journal Regional Anesthesia & Pain Medicine. 

 

Five minutes of prayer reduces pain and anxiety in primary care patients, randomized trial finds: A randomized controlled trial conducted at the University of Maryland School of Medicine has found that a five-minute session of proximal intercessory prayer (PIP) — in-person prayer offered by a trained volunteer — significantly reduced pain and anxiety in primary care patients compared to a music control group. The findings, published in the May/June 2026 issue of Annals of Family Medicine, suggest that proximal intercessory prayer may offer a practical, non-pharmacologic complement to conventional care, particularly for underserved populations.

 

Widely available drug combination is first effective treatment for Sjögren’s disease: A combination of two widely available anti-rheumatic drugs offers the first effective and affordable treatment for patients with Sjögren’s disease with systemic disease activity, according to new results from a clinical trial that was coordinated by UMC Utrecht. The study showed that treatment with leflunomide and hydroxychloroquine reduced disease activity in patients with moderate-to-severe disease, while maintaining a favorable safety profile. Lancet Rheumatology, published May 20, 2026

 

SMFM reaffirms acetaminophen as first-line medication for treating pain and fever during pregnancy:Acetaminophen remains the recommended first-line medication to treat pain and fever during pregnancy, according to an updated statement from the Society for Maternal-Fetal Medicine (SMFM). A comprehensive review of the available scientific evidence does not establish a causal relationship between acetaminophen taken during pregnancy and an increased risk of autism spectrum disorders and attention deficit and hyperactivity disorder (ADHD) in children, according to SMFM.  SMFM’s statement is based on a thorough review of recent studies and earlier research on acetaminophen during pregnancy. The newest studies vary in their findings on the potential association between prenatal acetaminophen exposure and risk of childhood neurobehavioral issues and have significant limitations in their study design.  

 

In middle-aged and older adults, migraine with aura associated with higher stroke risk: Migraine with aura was associated with an increased risk of ischemic stroke in middle-aged and older people, according to a study published May 20, 2026, in Neurology®Open Access Migraine without aura was not associated with an increased risk. The study does not prove that migraine with aura causes an increased risk of stroke, it only shows an association.

 

Low vitamin D levels linked to more pain after breast cancer surgery: Vitamin D deficiency is associated with more moderate to severe pain following breast cancer surgery and an increased consumption of opioid drugs, finds research published online in the journal Regional Anesthesia & Pain Medicine. Breast cancer patients with low levels of vitamin D (below 30 nmol/L) may benefit from taking supplements before undergoing a radical mastectomy, suggest researchers. 

 

Nationwide study finds reduced triptan use for migraine one year after semaglutide initiation for weight loss among women: A nationwide study from Denmark presented at this year’s European Congress on Obesity (ECO2026) in Istanbul, Turkey, shows that use of semaglutide (Wegovy) for weight management is associated with a 7% reduction in the use of triptan-class drugs for treatment in migraine one year after initiation. A sex-specific effect was observed, with women demonstrating an 8% reduction and men showing no significant change.

 

Scientists discover simple way to relieve arthritis pain without pills or surgery: A surprisingly simple walking tweak may offer new hope for millions living with knee osteoarthritis. In a year-long clinical trial, researchers found that slightly changing the angle of a person’s foot while walking reduced knee pain as effectively as common medications — and even slowed cartilage damage inside the joint. The Lancet Rheumatology

 

New procedure delivers lasting knee arthritis pain relief without surgery: A minimally invasive treatment that blocks inflammation-driving blood vessels in the knee provided significant pain relief and improved function for osteoarthritis patients, with benefits lasting at least a year. The procedure was safe, highly successful, and could offer a new alternative for people seeking relief before considering knee replacement. The treatment, known as genicular artery embolization (GAE), is an emerging nonsurgical procedure designed to target abnormal blood vessels that develop around arthritic knee joints. These excess vessels are believed to contribute to ongoing inflammation and pain. During the procedure, an interventional radiologist uses a thin catheter to reach the affected blood vessels and injects tiny particles that block blood flow to them. By shutting down these abnormal vessels, the treatment aims to reduce inflammation and relieve pain without surgery. The prospective single-center study enrolled 194 patients with osteoarthritis-related knee pain, including 114 women and 80 men. All participants had failed to achieve adequate relief after at least three months of conservative treatment, including physiotherapy, anti-inflammatory medications, and intra-articular injections. Radiology 

 

COMPLEMENTARY AND ALTERNATIVE MEDICINE

Psilocybin Effective for Resistant Depression in Real-World Trial: Psilocybin therapy showed significant improvement in depressive symptoms for treatment-resistant depression patients in real-world settings. Despite some adverse effects, the study supports its feasibility, though optimal dosing remains unclear. The study was published online on June 1 in The Lancet Regional Health. 

 

Large psilocybin dose briefly improved dementia in case study: A new case study describes the reversal of symptoms in a woman with advanced Alzheimer’s disease after taking magic mushrooms.  The findings hint that psilocybin may temporarily relieve symptoms, at least for some people. However, experts call for caution and larger studies. This is not an open-and-shut case, and the paper only outlines one patient’s story. Frontiers in Neuroscience 

 

Online cognitive behavioral therapy: An accessible solution for insomnia and anxiety in older adults: Cognitive behavioural therapies for insomnia (CBT-I) are increasingly being delivered online in order to improve accessibility. However, although insomnia and anxiety frequently occur together in older adults, few interventions address both conditions simultaneously. A new digital platform developed by researchers at the Centre de recherche de l'Institut universitaire de gériatrie de Montréal (CRIUGM), in collaboration with Concordia University, Université Laval and the Université de Montréal, aims to fill that gap. The results of a clinical trial, published in the journal Age and Ageing, highlight the feasibility and effectiveness of the program, with promising applications for improving mental health and sleep among older adults.

 

FDA APPROVALS

• Bemotrizinol as a new sunscreen ingredient, the first since 1999, offering broad-spectrum UV protection with low skin absorption. This innovation may enhance sunscreen options in the US by July 2026.

• Baxdrostat (Baxfendy, AstraZeneca) to lower blood pressure (BP) in combination with other antihypertensives in patients with uncontrolled hypertension.

• Afrezza, an inhaled insulin for children and adolescents

• The nonprescription sale of the Stelo Glucose Biosensor System manufactured by Dexcom for children ages 2 to 18 years.

•  Utebzi to treat complicated urinary tract infections

• Ambeivist to detect and visualize lesions with abnormal vascularity, in conjunction with MRI

•  Cypsedo to induce general anesthesia in adults undergoing surgery

• Xocova to use as post exposure prophylaxis of coronavirus disease 2019 (COVID-19) following contact with an individual who has COVID-19

• zaynich to treat complicated urinary tract infections, including pyelonephritis, caused by designated susceptible microorganisms

• Decnupaz to treat adults with blastic plasmacytoid dendritic cell neoplasm

• Hepcludex to treat chronic hepatitis delta virus infection in adults without cirrhosis or with compensated cirrhosis

• Welireg with pembrolizumab for renal cell cancer

• Rextovy an over the counter intranasal naloxone product for the emergency treatment of opioid overdose

 

                                                PREVENTION: Exercise

Cycling Linked to Higher Arrhythmia Risk in Middle-Aged Men: Middle-aged men who logged more hours of lifetime endurance exercise were more likely to report atrial fibrillation (AF) or atrial flutter, with cycling independently associated with higher odds of self-reporting either condition. published online on May 22, 2026, in European Heart Journal Open

 

Cycling linked to improved brain health and well-being in new review of 87 studies: A new peer-reviewed publication published in Frontiers in Sports and Active Living, highlights bicycling as a powerful, accessible tool for improving brain health and overall well-being. The review, carried out by researchers from Outride, University of Oklahoma, and Loma Linda University, synthesizes findings from 87 studies of cycling interventions across 19 countries, demonstrating that cycling has many positive impacts on psychological, social, affective, and cognitive outcomes, particularly in outdoor and multi-session programs. 


Just 2 Hours of Strength Training a Week May Help You Live Longer: A new study found that 90–120 minutes of strength training each week could help promote longevity.

Around 1.5 to 2 hours of weekly strength training lowered the risk of death from cardiovascular and neurological diseases, and death from any cause.  The findings add to the known health benefits of strength training, including bone health, improved balance, and weight management. The 30-year study, published on June 2 in the British Journal of Sports Medicine, found no additional benefits from more than 120 minutes of strength training. Strength training included exercises using weights or body weight, such as push-ups, lunges, and squats.

 

How Much Exercise Do You Need to Lower Your Risk of Cardiovascular Disease? A new study suggests that adults should aim for up to 4 times the current recommended amount of aerobic exercise per week for optimal heart health. The researchers say that adults should engage in aerobic exercise for 560–610 minutes per week to achieve a significant reduction in the risk of heart attack and stroke. They note that less fit adults may need to exercise more to achieve the same cardiovascular benefits. The results of the study were published on May 19 in published in the British Journal of Sports Medicine.

 

Pregnant women may reduce key health risk through less sitting, more light exercise: Recommendations are: Reduce sedentary time to fewer than eight hours each day. Engage in light physical activity for at least seven hours each day. Engage in approximately 22 minutes of moderate to vigorous physical activity, such as a brisk walk, each day. Get nearly nine hours of sleep each night. British Journal of Sports Medicine.

 

WVU study shows pregnant women who sit less and move more have fewer adverse outcomes: “The big finding was that women who were sitting for over 10 hours a day were developing twice as many adverse pregnancy outcomes as women who were sitting for shorter amounts of time,” “We were expecting to find that more sitting may be less healthy in pregnancy, but the magnitude of extra risk was bigger than we thought it would be. Our study supports the idea that a daily activity pattern with lots of prolonged sitting should be discouraged during pregnancy.” The study, published in the Journal of the American Medical Association, shows that two in five women who sat for 10 or more hours a day had an adverse pregnancy outcome, while only one in five women who sat approximately seven hours a day experienced an adverse pregnancy outcome.

 

Monash research suggests secret to healthy ageing could be hiding in skeletal muscle: Physical activity is one of the most powerful ways to combat biological ageing, which is the way our organs and tissue decline as we get older. The new research, published today in Science Advances, has used preclinical models to uncover the key role a protein found in skeletal muscle, NOX4, plays in this process. Physical activity and NOX4 naturally declines as we age, making it more difficult to achieve the health and anti-ageing benefits of exercise. The research shows lower levels of NOX4 are associated with muscle wasting and frailty, while restored levels are linked to better regulated metabolism and improved muscle mass and strength.

 

Four minutes of daily resistance training can quadruple fitness in older adults: Just four minutes of daily strengthening exercise dramatically increases key factors in quality of life for aging adults, according to a new study led by researchers at Penn State College of Medicine. Results published in PLOS One showed that strength — which impacts fall risk, longevity, independent living and more — significantly improved for adults aged 65 and older in as little as 12 weeks.

 

Activity and mood closely linked, study finds: The study analyzed more than 8,000 participants and 320,000 mood ratings across 67 datasets. Researchers found that people felt happier, more energetic and more positive shortly after being more active than usual. The pattern also worked in reverse: when people felt better than usual, they were more likely to be physically active soon afterward. 

 

Yes, Stair Climbing, Housework Count as Exercise. They Can Even Boost Your Mood: A large-scale study found that even 5 to 10 minutes of physical activity can improve energy levels and mood.  The findings, recently published inNature Human BehaviorTrusted Source, emphasize the value of light-intensity movement. Everyday activities, such as household chores, taking the stairs, or going for a short walk, can have immediate positive effects on well-being. The researchers identified a bidirectional connection between movement and mood. Translation: Movement boosts your mood, which in turn, only makes you want to move more. 

 

Smartphone Apps, Wearables Boost Activity in People With Cardiovascular Disease: Smartphones and wearable devices are effective at increasing physical activity among patients with cardiovascular disease, according to research published online June 17 in the Journal of the American Heart Association. Abstract/Full Text

 

 

                                                 PREVENTION: Sleep

Researchers harness the body’s internal clock to improve stroke recovery: A new study from scientists at the University of Rochester Medicine suggests that reinforcing the body's natural daily rhythms to improve sleep could help the brain recover after a stroke, pointing to a potential new strategy to improve brain waste clearance and outcomes long after the initial injury. The research, which was published in the Journal of Clinical Investigation, found that interventions designed to reinforce the body's natural circadian rhythms improved recovery in mouse models of stroke. The benefits were accompanied by improvements in the glymphatic system—the brain's waste-clearing network—and reductions in inflammatory molecules that can linger in the brain after a stroke. 

 

Long naps may increase the risk of chronic liver disease in people with diabetes: People with type 2 diabetes who nap longer than 30 minutes every day, regardless of their sleep patterns at night, increase their risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), according to a study being presented Monday at ENDO 2026, the Endocrine Society’s annual meeting in Chicago, Ill. 

 

                                               PREVENTION: Diet

Food Additives: Is New Evidence Raising Safety Questions? French researchers reported in three recent studies that certain food colorings may be associated with an increased risk of type 2 diabetes (T2D) and cancer, while several preservatives have been linked to a higher risk of hypertensionand cardiovascular disease. These additives are common ingredients in ultraprocessed foods, making the findings relevant to a large share of the population.

 

More Than 1 Drink a Day Linked to Health Risks, Clashing With U.S. Guidelines: A major new analysis suggests alcohol-related health risks may begin at lower levels of drinking.  Researchers found no clear health benefit from low-level alcohol consumption and concluded that both men and women should limit intake to no more than 1 drink per day. The study concludes that the risk of alcohol-related death begins at lower levels of consumption than previously suggested by federal guidelines. The research, published on June 8 in the Journal of Studies on Alcohol and Drugs, estimated that the risk of death and other health risks begins with relatively small quantities. Researchers concluded that current U.S. alcohol guidance should recommend no more than 1 drink per day for both males and females. The findings add to growing evidence that even moderate or socially accepted levels of drinking may carry long-term health risks, making individualized conversations about alcohol use increasingly important.

 

Drinking Alcohol May Lead to Ultra-Processed Food Cravings. Here’s Why: Drinking alcohol may cause people to over-consume savory ultra-processed foods. 

Researchers at the University of Sydney found that alcohol consumption may amplify a biological drive for salty, umami-flavored foods. The findings were recently published in Obesity ReviewsTrusted Source.

 

Drinking Alcohol Can Raise Your Risk of These 20 Health Conditions: A recent study found an association between alcohol consumption and 20 different health outcomes.  The findings show that any amount of alcohol may increase the risk for various cancers.  The researchers noted that the effects of alcohol can vary based on factors like sex, age, drinking patterns, and other behavioral risk factors.  The study found that there is no evidence to support sex-specific thresholds on alcohol guidelines. Nature HealthTrusted Source, 

 

Flavanol-Rich Fruits, Veggies May Be Best for Heart Health: Research has found that eating around 500 mg of flavanols per day can reduce your risk of death from cardiovascular disease. Not all fruits and vegetables are equal. Some have higher levels of flavanols than others. Fruit and veg with the highest flavanols include: plums, cranberries, blackberries, green tea, broad or fava beans, cherries, apples with skin, strawberries, blue berries, pinto beans.  Healthline 

 

An Avocado a Day May Keep Diabetes, Hypertension, and Obesity at Bay: Research suggests that females who eat 30–38 grams of avocado per day may have a lower risk of diabetes.  A recent study also found that eating one avocado and 1 cup of mango each day may help lower blood pressure in people with prediabetes.  A new study found that eating fresh avocado each day may help improve your body’s blood sugar response, lower diabetes risk, and reduce cardiometabolic risks. Healthline 

 

Eating More Watermelon May Help Prevent Heart Disease: Research shows that watermelon may help improve heart health and lower your risk of heart disease. 

It also shows that this fruit may aid in overall nutrient intake for both adults and children.  Individuals who consume more watermelon may have a greater intake of essential nutrients, including fiber, potassium, and vitamin C. Watermelon may also help improve hydration.

 

Can fasting fight gum disease? Scientists find surprising link: A low-calorie fasting-style diet significantly reduced inflammation linked to gum disease in a small clinical study. The findings suggest that what people eat may influence gum health almost as much as what they do with a toothbrush. Journal of Clinical Periodontology

 

Tea can improve your health and longevity, but the way you drink it matters: The review confirms that tea, particularly green tea, plays a crucial role in preventing cardiovascular diseases (CVDs), obesity, diabetes, and certain types of cancer. Tea’s neuroprotective effects, ability to reduce muscle loss in seniors, and its anti-inflammatory and antimicrobial activities further highlight its potential health-promoting properties. However, the study also identifies potential health concerns, particularly with bottled and bubble teas, which may contain harmful additives like artificial sweeteners and preservatives. A study published in Beverage Plant Research

 

Scientists say guava juice could make iron supplements work better: Researchers found that drinking guava juice may significantly improve anemia by helping the body absorb iron more efficiently. In a review of 17 studies, women and teenage girls who consumed guava juice — especially with iron supplements — experienced noticeable increases in hemoglobin levels. Since guava contains far more vitamin C than oranges, scientists believe it could become a simple, affordable nutrition tool in regions where anemia is widespread. BMJ Nutrition Prevention & Health 

 

Surprising research reveals why you shouldn't add bananas to your smoothies: Researchers found that adding bananas to berry smoothies can dramatically reduce the body’s ability to absorb healthy flavanols. The surprising discovery shows that even simple food combinations can change how much nutrition your body actually gets. Materials provided by University of California – Davis

 

Can’t stick to a diet? Try intermittent fasting for weight loss: An Adelaide University study focusing on the psychological aspects of both intermittent fasting and calorie restriction, compared the effects both diets had on eating behaviours, mood, sleep and quality of life. Although both diets led to similar amounts of weight loss, those on the fasting diet didn’t feel as though they needed to make major changes to their eating behaviours – such as monitoring overeating or counting calories - in order to lose weight. This contrasts with the calorie restriction diet, where participants reported consciously having to think about restricting their food intake and avoiding overeating. That improved control accounted for 15% of their weight loss. Clinical Nutrition,

 

Plant-forward and low-insulinemic diets may help reduce weight gain and obesity risk during menopause, long-term study finds: A large long-term study of nearly 40,000 women has found that women who eat more plant-based, low-insulinemic foods may gain less weight and have a much lower risk of developing obesity during the years around menopause. A low-insulinemic diet refers to a diet that is less likely to cause repeated spikes in insulin, a hormone that helps regulate blood sugar and fat storage. Published in JAMA Network Open, the study analysed data from 38,283 women enrolled in the Nurses’ Health Study II from 1989 to 2019, focusing on approximately 12 years around menopause.

 

Cows v plants: which milk delivers the greatest health benefits: New research at Edith Cowan University (ECU) has shed new light on the growing debate between cow’s milk and plant-based alternatives.  Results of the study suggest that cow’s milk has the edge over plant-based alternatives when it comes to bone strength and nutrient absorption.   The review by ECU’s Nutrition and Health Innovation Research Institute examines the “milk matrix” - the natural structure of milk that brings together nutrients, fats, proteins, vitamins, minerals and bioactive compounds.  “Milk is more than just calcium, protein and fat - it’s a complex whole food, and how its nutrients are packaged together is more important than initially thought,” Associate Professor Therese O'Sullivan said.  Milk contains more than 100 nutrients and bioactive substances, arranged in a unique physical structure.    “Exploring the dairy milk matrix beyond isolated nutrients – a narrative review”

 

 

                              PREVENTION: Vitamins/Supplements

Natural Supplements Linked to Rising Cases of Serious Liver Injury: Herbal and dietary supplements (HDS) marketed for wellness, weight loss, inflammation, and energy boosting are increasingly being linked to severe liver injury, hepatologists warned here at the European Association for the Study of the Liver (EASL) Congress 2026.

 

Urinary Symptoms in Men: Do Herbs Like Saw Palmetto Help? Herbal remedies like saw palmetto and beta-sitosterol may offer modest relief for mild-to-moderate lower urinary tract symptoms in men, but their effectiveness is inconsistent and less than pharmacologic treatments. Comprehensive evaluation and realistic expectations are essential. Medscape

 

Vitamin C may help preserve brain gray matter volume as we age: As our body naturally ages, so does our brain, causing structural and connectivity changes.  Previous research shows that consuming certain nutrients, like vitamin C, may assist with healthy brain aging. A new study found having low levels of vitamin C in blood plasma is correlated with a lower brain gray matter volume and connectivity during aging. PLOS OneTrusted Source 

 

Millions take calcium and vitamin D for stronger bones. A major review finds little benefit: For years, calcium and vitamin D supplements have been promoted as a simple way for older adults to protect their bones and prevent falls. But a massive review of nearly 154,000 people found that calcium, vitamin D, or a combination of both provided little to no meaningful protection against fractures or falls for most older adults. BMJ

 

This popular brain supplement was linked to shorter lifespans in men: A large-scale study suggests that men with higher levels of the amino acid tyrosine may have shorter lifespans, potentially losing close to a year of life expectancy. The finding is especially intriguing because tyrosine is commonly associated with brain health and is often used in supplements aimed at boosting focus and performance. Aging

 

Ancient Chinese medicine could transform hair loss treatment: A traditional Chinese medicinal root used for over a thousand years is attracting new scientific attention for its potential to combat hair loss. Studies suggest Polygonum multiflorum can block harmful hormones, activate hair-growth signals, protect follicles, and boost blood flow to the scalp. Researchers say the herb’s effects align remarkably well with both ancient descriptions and modern hair biology. Journal of Holistic Integrative Pharmacy 

 

The supplements older adults actually need and the ones they don't: Supplements are often marketed as shortcuts to better health, but for many older adults, the real issue is whether they have a specific deficiency. Vitamins like B12 and D can play an important role when levels are low, while protein may be one of the most overlooked nutrients for maintaining strength and independence. More isn’t always better, though—some supplements can cause harm or interact with medications. The Conversation 

 

Scientists are raising new questions about vitamin B12 and cancer: Vitamin B12 has long been seen as a health hero, helping the body make red blood cells, repair DNA, and keep nerves functioning properly. But scientists are discovering that the story may be more complicated than simply “more is better.” While too little B12 can damage DNA and raise cancer risk, some studies suggest that extremely high levels — especially from long-term high-dose supplements — may also be linked to certain cancers or poorer outcomes in cancer patients. The Conversation 

 

Scientists warn popular vitamin D supplement may have a “previously unknown” downside: A surprising study suggests vitamin D2 supplements may reduce the body’s levels of vitamin D3 — the more effective form of vitamin D. Researchers found D3 not only boosts vitamin D status more efficiently, but may also play a unique role in helping the immune system fight off viruses and bacteria. The discovery is prompting scientists to rethink whether D3 should become the preferred choice for supplementation. Nutrition Reviews

 

A daily probiotic may help relieve depression and anxiety: A small clinical trial suggests that probiotics may offer a surprising mental health boost for older adults with depression. Seniors who took a daily probiotic alongside their regular antidepressant treatment experienced slightly greater improvements in depression and anxiety symptoms than those who received a placebo. Journal of the American Geriatrics Society 

 

                                                    PREVENTION: Other

The Bare Minimum You Need to Do to Add a Year to Your Life: Minimal lifestyle changes, like adding 5 minutes of sleep, 2 minutes of moderate activity, and half a serving of vegetables daily, can extend life by a year, highlighting the power of small, combined health improvements. In 2025, Stamatakis gained notice with a Nature Communications paper that showed each dose of 60 seconds of daily vigorous exercise could add years to lifespan and reduce the risk for cardiometabolic disease and cancer. Now, drawing from UK Biobank data, his team’s latest findings show a synergistic effect that “argues against an all-or-nothing approach,” Stamatakis said. “If a patient is struggling to make a large change in one area, it may still be worthwhile to pursue smaller gains across several domains at once.”

 

Diet, weight loss, and 150 minutes of exercise may protect against chronic diseases in prediabetes: A new study has found that, in a group of adults with prediabetes, lifestyle modifications were more effective at preventing multiple chronic conditions, including type 2 diabetes, than metformin or placebo. JAMATrusted Source 

 

Colorectal Cancer Screening Guidelines Include New Alternative to Colonoscopy: The American Cancer Society (ACS) has updated its guidelinesTrusted Source for colorectal cancer screening to include new blood-based and at-home stool tests. The new blood test screens for tumor DNA, while the at-home tests look for DNA, RNA, and blood markers in stool samples. The updated guidelines still retain ACS recommendations for starting colorectal cancer screening at age 45 and having colonoscopies done every 10 years for people who are at average risk of colorectal cancer.

 

Reversing prediabetes cuts risk of deadly heart problems by 58%: Bringing blood sugar levels back to normal may dramatically reduce the danger posed by prediabetes. Researchers found that people who reversed prediabetes cut their risk of cardiovascular death or hospitalization for heart failure by 58% and lowered their chances of major heart problems such as heart attacks and strokes by 42%. The benefits lasted for decades and were seen across large long-term studies in both the U.S. and China. The Lancet Diabetes

 

Your brain can keep improving into your 90s, study finds: A three-year study of nearly 4,000 adults ranging from age 19 to 94 found that brain health can improve at any age, challenging the common belief that mental sharpness must decline as we get older. Participants spent just a few minutes a day on brain-training activities, and researchers found measurable gains across multiple aspects of brain health, including thinking clarity, emotional well-being, and sense of purpose. Scientific Reports 

 

                                                      TREATMENT

Older Drug Reprograms White Blood Cells, Improves Blood Sugar in Type 1 Diabetes: BCG immunotherapy reprograms white blood cells, significantly improving blood sugar control in type 1 diabetes patients, even without a functioning pancreas. This decades-old treatment reduces insulin use and normalizes blood sugar levels. Reuters Health

 

Fecal Transplant Curbs Alcohol Cravings: Fecal microbiota transplantation (FMT) significantly improved alcohol abstinence and reduced relapse rates in patients with alcohol-associated cirrhosis. The study suggests modifying the gut microbiome may reduce alcohol cravings, offering a novel therapeutic approach.  European Association for the Study of the Liver (EASL) Congress 2026.

 

GLP-1s Tied to Musculoskeletal Benefits in Obesity: In adults with obesity and without diabetes, using GLP-1s vs other antiobesity medications was significantly associated with a decreased risk for osteoporosis, major osteoporotic fractures, degenerative disk disorders, and osteoarthritis.  published online in Obesity.

 

Oral GLP-1 Orforglipron Performs Well in Phase 3 T2D Trials: Orforglipron, an oral GLP-1 receptor agonist, demonstrated superior A1c reduction and weight loss in type 2 diabetes patients compared to dapagliflozin and oral semaglutide, despite a slightly worse tolerability profile, according to phase 3 trials. American Diabetes Association (ADA) 2026 Scientific Sessions.

 

GLP-1 RAs May Independently Boost Testosterone Levels: Patients treated with a GLP-1 receptor agonist for weight loss showed a significant increase in both total testosterone (TT) and free testosterone (FT), according to new data presented at the American Urological Association (AUA) 2026 Annual Meeting.

 

Retatrutide Data Show Dramatic Weight Loss, Other Benefits: The investigational triple GLP-1/GIP/glucagon receptor agonist retatrutide produced significant weight loss and A1c reduction in people with type 2 diabetes (T2D), according to full data from the TRANSCEND-T2D-1 trial.  And in people with obesity without T2D, the drug led to significant weight loss and improvements in osteoarthritis knee pain and obstructive sleep apnea, further results from the TRIUMPH-1 trial showed.  Improvements in cardiovascular risk factors were seen in both trials. Both studies were presented here at the American Diabetes Association (ADA) 2026 Scientific Sessions, and results from TRANSCEND-T2D-1 were simultaneously published in The Lancet. 

 

Survodutide weight-loss drug may reduce harmful fat while preserving muscle: In the phase 3 SYNCHRONIZE-1 trial, participants with obesity or overweight treated with Survodutide achieved up to 16.6% mean weight loss over 76 weeks. New analyses showed Survodutide reduced visceral fat by up to 34% and liver fat by up to 63.1%, suggesting benefits beyond overall weight reduction.  The majority of weight loss came from fat mass, with analyses indicating that lean body mass was largely maintained.

In people with obesity or overweight and metabolic dysfunction-associated steatotic liver disease (MASLD), around 60% of participants achieved normalization of liver fat levels.  2026 American Diabetes Association (ADA) Scientific Sessions

 

Solutions Emerging for Post-GLP-1 Weight Regain: Patients discontinuing GLP-1 treatments often regain weight rapidly, but emerging strategies like endoscopic procedures and new oral medications show promise in maintaining weight loss. These alternatives may offer cost-effective, long-term solutions. Medscape 

 

Weight loss drugs slash risk of 4 types of cancer by 50% or more, study finds: Between December 2014 and June 2025, 38% of study participants received a GLP-1 prescription, and the remaining 62% received diet and exercise counseling.  At the study’s conclusion, researchers found that participants who took GLP-1 medications containing semaglutide or tirzepatide had a 41% decrease in their overall risk of developing an obesity-related cancer.  “A 41% reduction across more than 229,000 patients is not a small signal,” Kamat said. “That is the kind of number that, in any other context, would already be driving clinical guidelines.”  Even higher cancer risk reductions were found in specific cancers, including a 58% lower risk of endometrial cancer. 

 

GLP-1s Like Ozempic, Wegovy Linked to Surprising Drop in Violent Behavior: A new study found that GLP-1 drugs like Ozempic and Wegovy may also help reduce violent behavior among adults.  The researchers found that higher levels of alcohol use and impulsivity were associated with violent behavior overall. However, the behaviors were weaker among GLP-1 users. The results were published on June 17 in CriminologyTrusted Source.

 

Can Bariatric Surgery Benefit Older Adults With Obesity? Metabolic-bariatric surgery (MBS) in patients aged 65 years or older resulted in long-term meaningful weight loss and remission of obesity-related conditions, although complication rates of about 8% were noted.  published online on May 22, 2026, in Obesity Surgery.

 

Drug Combo May Be a Better Choice for Some Men With BPH: Men with benign prostatic hyperplasia (BPH) may benefit from a combination of tamsulosin and mirabegron, according to new research presented at the American Urological Association (AUA) 2026 Annual Meeting.

 

Upping Fluids After Kidney Stones Helps Prevent Recurrence Even When Not Hitting Goals, Analysis Finds: Increasing fluid intake after kidney stones reduces recurrence risk, even if urine output goals aren't met. Patients boosting urine volume by 438 mL daily saw a 24% lower recurrence risk, highlighting fluid intake's importance.  American Urological Association (AUA) 2026 Annual Meeting. 

 

Cooling Vest May Reduce Body Fat in Obesity: Daily cold exposure using cooling vests for 2 hours each morning over 6 weeks reduced body weight and body fat mass in adults with overweight or obesity. The intervention improved thermal comfort and cold-induced carbohydrate oxidation while reducing cold perception over time.  33rd European Congress on Obesity (ECO) 2026.

 

Can Fasting Around Chemo Improve Ovarian Cancer Outcomes? Fasting around chemotherapy may enhance treatment response and progression-free survival in advanced ovarian cancer patients, according to a small phase 2 trial. The approach is simple, cost-effective, and warrants further research for validation. The findings, reported at a press briefing ahead the American Society of Clinical Oncology (ASCO) 2026, hint at a straightforward measure to potentially improve patients’ outcomes.

 

Groundbreaking New Drug Nearly Doubles Pancreatic Cancer Survival: In a phase 3 clinical trial, the drug daraxonrasib significantly improved survival rates of participants with pancreatic cancer who had previously been treated with chemotherapy.

The researchers found that daraxonrasib reduced the overall risk of death by 60% compared with people with advanced pancreatic cancer who were treated with chemotherapy. The medication also helped shrink or eliminate tumors among participants in the trial. The findings were recently published in the New England Journal of Medicine and presented at the American Society of Clinical Oncology (ASCO) 2026 annual meeting from May 29 to June 2 in Chicago, IL.

 

Menopause hormone therapy slashes risk of low bone density, new data shows: The researchers found that women taking menopausal hormone therapy had a 69% lower risk of low bone mineral density than those not using hormone replacement.  ENDO 2026

 

Common heart drug taken by millions found useless — and possibly dangerous: A massive international study could upend 40 years of heart attack treatment. Researchers found that beta blockers—routinely prescribed after uncomplicated heart attacks—offered no real benefit for patients whose heart function remained normal, despite being given to millions worldwide. Even more surprising, women taking the drugs faced a higher risk of death, repeat heart attack, or hospitalization for heart failure compared to women who didn’t receive them. The New England Journal of Medicine 

 

PFS Improved With Talquetamab in Relapsed or Refractory Multiple Myeloma: Among patients with relapsed or refractory multiple myeloma who had previously received at least one line of therapy, talquetamab plus daratumumab and pomalidomide (Tal-DP) and talquetamab plus daratumumab (Tal-D) yield longer progression-free survival than daratumumab plus pomalidomide and dexamethasone (DPd), according to a study published online June 13 in the New England Journal of Medicine. 

 

                                                                        OTHER

COVID History May Prompt New Allergies: A history of SARS-CoV-2infection significantly increased the risk of developing six allergic conditions, based on data from more than 760,000 adults and children. In a new study published in the Annals of Allergy, Asthma & Immunology, the researchers assessed data from the TRICARE Management Activity’s Military Health System Data Repository, a US Department of Defense healthcare claims database, from July 2018 to December 2022 that included inpatient and outpatient medical records, COVID lab results, and dispensed prescriptions.

 

Measles, Whooping Cough Rising Due to Low Vaccination Rates: Doctors are reporting what they describe as an alarming rise in a variety of serious illnesses due to declining vaccination rates. Measles is a significant concern amid ongoing outbreaks in the United States, but concerns about whooping cough, rotavirus, and other diseases are also mounting. Children who aren’t vaccinated appear to be bearing the brunt of these illnesses, but officials also note an increase in unvaccinated adults requiring hospitalization, including some who refuse tetanus shots and blood transfusions. The news comes a week after President Donald Trump signed an executive order reaffirming an assessment by the Department of Health and Human Services (HHS) that aligns “the United States’ childhood vaccine practices with scientific evidence and best practices from peer, developed countries.” Healthline 

 

Beer, Body Scent May Make You a Mosquito Magnet. Can DEET Help?

Research shows that mosquitoes may be more attracted to some people than others. 

A 2026 preprint study found that mosquitoes are also more attracted to those who drink beer compared to those who don’t. Other recent studiesTrusted Source have found that mosquitoes are attracted to the carbon dioxide (CO2) humans exhale. Older studies suggest that mosquitoes may be attracted to chemical odors emitted by your skin. DEET has long been considered the gold standard repellent for protection against mosquito bites. However, a new study found that mosquitoes may have learned how to associate DEET with food and even become attracted to it.  Of course, this doesn’t mean you should stop using DEET altogether. Any protection against mosquitoes is better than none at all.

 

Only 20% of Sunscreens Meet Safety Standards. What to Know Before You Buy: Only about 20% of sunscreens meet leading safety and efficacy standards, according to a recent report from the Environmental Working Group (EWG).  Mineral sunscreens are generally considered safer, but the best sunscreen is one you use consistently and reapply regularly. Broad-spectrum SPF 30 to 50, proper application, and regular reapplication are the keys to effective sun protection. Healthline

 

It matters what liquid you take your medication with: Some alkaline mineral and medicinal waters may weaken the enteric coating of medications within just a few minutes, potentially reducing their effectiveness, according to a new study by Semmelweis University. The study, published in Pharmaceutics, found that if the active ingredient is released too early in the stomach rather than in the intestinal tract, it may reduce – and, in extreme cases, even eliminate – the effectiveness of certain anti-reflux, gastroprotective, psychiatric, or anti-inflammatory pain-relief medications. Alkaline bottled waters with high mineral content caused the greatest changes in the protective coating surrounding the active ingredient-loaded particles

 

ACOG Issues Vaccine Schedule for Pregnant, Lactating, Postpartum Individuals: The American College of Obstetricians & Gynecologists (ACOG) has published a simplified immunization schedule for pregnant, breastfeeding, and postpartum individuals that it said represents the best evidence for four routinely recommended vaccines. “ACOG has made the decision to formally release its own immunization schedule to provide and communicate clear evidence-based guidance and to address the growing vaccine misinformation that is circulating,” said Christopher Zahn, MD, chief of clinical practice and health equity and quality at the organization, in a briefing with reporters. The new ACOG schedule is endorsed by 13 medical societies and health organizations, and, for the first time, differs from recommendations issued by the CDC’s Advisory Committee on Immunization Practices (ACIP) for use during pregnancy.

 

New guideline highlights obesity’s central role in heart, kidney, and metabolic disease: Now, the first-ever clinical guideline on CKM syndrome from the AHA and the American College of Cardiology (ACC), published in CirculationTrusted Source, highlights the role of excess weight, positioning it as a key driver of Cardiovascular-Kidney-Metabolic (CKM) syndromerather than simply a risk factor.

 

Scientists thought brain inflammation was driving long COVID but the scans told a different story: A new brain imaging study has found no evidence of widespread brain inflammation in patients suffering from prolonged symptoms after COVID-19 infection. Instead, the most severe long COVID symptoms were associated with increased brain activity in regions involved in mood and emotion. Journal of Neurology 

 

 

Saturday, May 30, 2026

Life with Chronic Conditions: Myths of Trauma

If it feels like you hear the term “trauma” used a lot and in many different situations, you aren’t mistaken. Trauma has become a buzzword for educators, psychologists, doctors and beyond. Americans are obsessed with trauma. But what is it and does it deserve the hype?

I’ve been following the work of Dr. George Bonanno since I worked in AIDS. A Professor of Clinical Psychology at Teachers College, Columbia University, he’s an internationally known expert on trauma and resilience. 

 

In 2025 he did an interview for Big Think  as part of their series The Roots of Resilience. If you think that trauma leaves irreversible scars, the science, however, shows the opposite. We’re basically wired for resiliency. 

 

There are at least three very much interrelated misconceptions about trauma right now. One is that anything very difficult and unpleasant, hard, can cause trauma or is a trauma. Another is that anything that we consider a trauma has lasting emotional damage. And the third, which is very pernicious, is that there are hidden traumas that we're carrying around PTSD like traumas in us somewhere, and they're hidden from us, yet they are continuing to harm us and to cause difficulties in our life. Even saying that, I have to confess, even saying that makes me feel funny because as a scientist, when you say, "we carrying around with us hidden traumas," I want to say, "where are they?"

 

In addition to listening/reading Bonanno’s talk, definitely recommend checking out The Roots of Resilienceseries which explore “Why the world is reorganizing for instability.”

Wednesday, May 20, 2026

Life with Chronic Conditions: Take an Arts Break for Better Health

For many years on Wednesday’s I would post a “Take a Break.” Having posted enough that you could do two a day for over a year, I only occasionally do one. 

In last week’s Journal Watch there was an interesting article  about some doctors in Canada who 'prescribed art to their patients, giving them free access to a local museum. The idea was that by meandering amongst the masterpieces and pondering the paintings, patients could achieve better physical and mental health outcomes.

 

A new study from the United Kingdom suggests that this was a good idea, as the arts appear to affect biological hallmarks of aging. Scientists from University College London (UCL) found that a weekly arts or cultural activity could slow the pace of aging about as much as exercising once a week. "Our study provides the first evidence that arts and cultural engagement is linked to a slower pace of biological aging," says senior author and epidemiologist Feifei Bu from UCL.

 

These activities could include visiting a museum or library, attending an art exhibit, crafting, painting, singing, dancing, and much more. Participants in the study who did one of these activities at least once a week showed slower signs of aging than those who had less of a cultural repertoire. The findings were strongest among middle-aged adults, and the greater the diversity of arts and cultural activities, the better the signs of aging.

 

Check out try the Take a Break Pinterest Board for lots of different ways to take an art break. 

 

Saturday, May 16, 2026

Journal Watch May 2026

                                                                       😓PAIN

Surgery may worsen knee osteoarthritis: A common knee surgery — the partial removal of meniscus cartilage — may provide little benefit to people with knee osteoarthritis and may actually worsen their prospects for long-term knee health, according to new research from Finland, whose findings are reported in a correspondence paper published in The New England Journal of Medicine.

 

Mental defeat – the hidden experience fuelling daily suffering in chronic pain: Published in the journal PAIN, researchers found that when people feel mentally defeated, they are more likely to focus on their pain, see it as damaging to their identity and future, and withdraw from everyday activities, making it a critical factor in reduced quality of life. “Pain is not something that can simply be taken away, it is someone’s reality. But how people relate to their pain, and the meaning they attach to it, can add an extra layer of distress that we might be able target with the right interventions.”

 

Certain migraine prevention drugs associated with reduced risk of glaucoma: A type of drug used to prevent migraine may be associated with a reduced risk of glaucoma, according to a study published May 6, 2026, in Neurology® The study compared 36,822 people who took calcitonin gene-related peptide (CGRP) inhibitor drugs to prevent migraine to the same number of people who took other types of migraine prevention drugs. It does not prove that CRGP inhibitor drugs directly cause the reduced risk of glaucoma; it only shows an association.

 

Pioneering study confirms the benefits of total hip arthroplasty: Total hip arthroplasty leads to the best outcomes in the treatment of moderate-to-severe hip osteoarthritis, according to a new study by the University of Eastern Finland and Kuopio University Hospital. During a one-year follow-up, surgery combined with conservative treatment was found to relieve pain and improve functional capacity and quality of life more effectively than conservative treatment alone, which was based on an exercise programme. The Bone & Joint Journal

 

Central nervous system a key player in diabetes pain: More than 50% of people with diabetes develop diabetic peripheral neuropathy. In about one-third of cases, nerve damage results in painful sensations such as burning, tingling, or shooting sensations in the feet. Pain often worsens at night and disrupts sleep and ultimately reduces a person's ability to work, or to carry out everyday activities. Changes within the central nervous system, including the brain and spinal cord, can be a key reason for pain in people with diabetes, and future treatments could focus on restoring the brain’s pain blocking systems, according to new research.  Pain Modulation and Central Sensitization in Painful Diabetic Peripheral Neuropathy: Updated Narrative Review and Future Directions 

 

New study finds link between difficulty identifying emotions and higher chronic pain levels: A large, two-year study led by researchers at Johns Hopkins Medicine and consisting of more than 1,400 adults living with chronic pain across the United States found that people who struggle to identify and describe their emotions experience greater disruption to daily life from pain over time due to increased psychological distress. The study examined how alexithymia — a trait marked by difficulty recognizing and expressing emotions — affects pain outcomes. While previous research has linked alexithymia to worse pain, this study is among the first to show how and when that effect unfolds over time. The study’s findings were published March 26 in the journal Health Psychology.

 

Trial shows relief for those living with chronic angina: A new UK-led study has found that angioplasty with stenting  to reopen a fully blocked heart artery can significantly reduce chest pain and improve people’s quality of life. The results have been published in the JACCjournal.

 

‘Leave-nothing-behind’ strategy works as well as drug-eluting stent for heart attack and chest pain patients: A new sub-study suggests that using a sirolimus-eluting balloon (SEB), a drug-coated balloon, can reduce the number of stents a patient may need, making it a safe and effective way to treat certain heart attacks or unstable chest pain. Society for Cardiovascular Angiography & Interventions "Sirolimus Eluting Balloons for Patients with Acute Coronary Syndrome – Evidence from the SELUTION DeNovo Trial"

 

ADHD and chronic pain, an overlooked connection: A new study, led by researchers from the University of Tokyo, involving nearly 1,000 patients in Japan suggests that attention deficit hyperactivity disorder (ADHD)-related traits may be associated with and may contribute to chronic pain. The connection seems solid but indirect: ADHD-related traits appear to impact how people perceive pain through increased anxiety, depression and negative thought patterns. Scientific Reports 

 

Combining cannabis with opioids offers no added pain relief for knee arthritis patients: Combining cannabis with an opioid did not improve acute pain for people with knee arthritis, according to results of a study published in the May issue of Anesthesiology, The results of a randomized, double-blind, placebo-controlled study found no added benefit while undergoing laboratory pain testing. The findings showed neither cannabis nor opioids alone provided significant pain relief and using them together did not improve results.

 

Mobile App for Hand Osteoarthritis Improves Pain and Function Compared to Usual Care: The Happy Hands app significantly improved pain and hand function in osteoarthritis patients compared to usual care, with 47% showing improvement. The app's effectiveness suggests a promising self-management tool, despite a high dropout rate.  World Congress on Osteoarthritis (OARSI) 

 

Early Knee OA Lifestyle Program Insufficient for Reducing Weight to Lessen Disease Progression: A combined lifestyle intervention program was not sufficient in routine primary care for enabling participants with overweight or obesity and early knee osteoarthritis (OA) symptoms to lose a modest amount of weight to reduce risk for OA progression, according to research presented at the World Congress on Osteoarthritis (OARSI) 2026 Annual Meeting.

 

 

              COMPLEMENTARY AND ALTERNATIVE MEDICINE

Edible Cannabis and Pain, Sleep, and Mental Health Management in Older Adults: A new study by researchers from University of Utah Health and University of Colorado Boulder reveals that many older adults start cannabis seeking more effective or non-pharmaceutical options to manage sleep, pain, or mental health, and that many people base their decisions on word of mouth rather than discussions with health care providers. JAMA Network Open.

 

Is cannabis safe after 65? Stanford experts reveal 5 risks older adults should know: Cannabis use among older adults is rising fast, but today’s marijuana is far more potent than many people realize — and experts warn the risks may be underestimated. Stanford Medicine specialists say modern cannabis can increase the chances of heart problems, falls, memory issues, dangerous drug interactions, and even addiction, 

 

TBI survivors turn to psychedelics for symptom relief: A new study from the University of Victoria (UVic) has identified a segment of traumatic brain injury survivors who are using psychedelics to self-medicate for cognitive, mood and somatic symptoms such as headaches. In a first-of-its-kind study, clinical psychology researchers analyzed more than 6,100 responses collected from the global psychedelic survey. Researchers found that nearly 1,200 respondents reported using psychedelics to treat or manage a physical health condition. Researchers found that respondents with TBIs most often used psilocybin every two to five months or every six months to treat their symptoms, using a mix of microdoses and larger doses. Other respondents reported self-medicating with LSD/acid and ketamine. Not only are people with TBIs experimenting with psychedelics to manage mood, cognitive and somatic symptoms—they are finding relief. When asked to rate how effective their psychedelic use was on their TBI-related symptoms, 90 per cent of the sample self-reported some level of symptom improvement.

 Psychedelics for the management of symptoms of traumatic brain injury: Findings from the global psychedelic survey,

 

Cognitive-behavioral therapy shows promise managing menopausal insomnia and hot flashes: New study demonstrates that cognitive-behavioral therapy intervention can produce meaningful short-term improvements in insomnia severity, hot flash interference, sleep self-efficacy, and depressive symptoms. “Cognitive behavioral therapy for menopausal insomnia in perimenopausal and postmenopausal women with insomnia and nocturnal hot flashes: a randomized-controlled pilot trial.”

 

Nature-based group activities improve wellbeing among older adults experiencing loneliness: Focusing on nature, including outdoor excursions and contacts with the natural world, the activities boosted wellbeing and health through peer support and activity content. “Group activities once a week over just a nine-week period can already reduce loneliness in research subjects and improve their sleep and memory, as well as their sense of connection to nature. Our study also highlighted the need for older adults in care homes to visit outdoor environments and nature more 

 

                                      PREVENTION: Exercise

This Type of Exercise Can Help You Build More Muscle With Less Effort: A lesser-known type of exercise can build strength and improve fitness while remaining accessible to less active individuals. Eccentric exercises like lowering weights or walking downhill can generate more force with less energy while supporting muscle, heart, and even brain health. Eccentric exercise may help build muscle strength with less strain on the body, according to an article recently published in the Journal of Sport and Health Science. It may also offer specific advantages over concentric exercise for muscle rehabilitation and even brain health.

 

Your Fitness Level After 40 Can Add Years to Your Life and Boost Health: According to a recent study, your level of cardiorespiratory fitness in midlife can not only help determine how long you live, but also how many of those years you spend in good health. The study showed that adults with higher midlife cardiorespiratory fitness lived longer, developed fewer chronic diseases, and spent more years free from serious illness than those with lower fitness. The results were recently published in the JACC

 

Increasing daily steps may boost recovery after surgery: A study suggests that each additional 1,000 daily steps after surgery was linked to better outcomes, including 18% fewer complications, 16% lower readmission risk, and 6% shorter hospital stays. 

Step count was also a stronger predictor of recovery than heart rate variability or self-reported wellness scores.  The association between higher step counts and improved outcomes held across different types of surgeries and patient health profiles.  The findings indicate that data from wearable devices could help clinicians monitor recovery in real time, guide discharge decisions, and identify patients who may need extra support. Journal of the American College of Surgeons, 

 

A simple 30-second sit-to-stand test that can predict how well you age: In just 30 seconds, a simple movement like standing up from a chair can reveal a person’s risk of falls, hospitalization, and even death. Muscle power is not only essential for maintaining independence, but also a powerful biomarker of how well we age. Measuring it is simple; its implications are profound. Journal of Sport and Health Science 

 

8,500 steps a day can help dieters keep weight off: New research presented at the European Congress on Obesity (ECO 2026) in Istanbul, Turkey and published in International Journal of Environmental Research and Public Health shows that doing around 8,500 steps a day can help people keep weight off after dieting. 

 

The critical role of exercise in the GLP-1 era: As GLP-1 receptor agonists reshape obesity treatment, a new medical perspective published in the Journal of the American Medical Association, or JAMA, underscores a persistent gap in care: integrating exercise into weight management in ways patients can sustain. The perspective, “The Conundrum of Exercise for Weight Management in the GLP-1 Receptor Agonist Era,” examines the evolving role of physical activity alongside medications such as semaglutide, liraglutide and other GLP-1-based therapies

 

High-intensity interval training shows strongest vascular benefits in cardiovascular patients: A network meta-analysis identifies high-intensity interval exercise as the most robust strategy to improve endothelial function, outperforming moderate continuous training across patients with cardiovascular disease. The findings, published in the European Journal of Preventive Cardiology, are based on a systematic review and network meta-analysis of 37 studies that included 6,818 adult patients with coronary artery disease or chronic heart failure.

 

Two exercise types help reduce blood pressure in those with hypertension: Research links combined aerobic and resistance exercise, as well as high intensity interval training (HIIT), with significant reductions in 24-hour blood pressure in adults with hypertension.  The analysis suggests that aerobic exercise was the most consistently effective form of exercise for lowering blood pressure, with reductions observed during both daytime and nighttime periods.  Evidence suggests that aerobic and combined exercise should remain the primary recommendations for lowering blood pressure, with further research needed for other activities.

 

For older adults with mild cognitive impairment, exercise can be crucial to sleep quality Study finds that while both light and vigorous activity can reduce sleep disturbances, high-intensity workouts provide the greatest benefit — offering new hope for quality rest and dementia prevention. For their study, published in the journal Digital Health, Lee and Kim used Oura Rings to measure the effects of different intensities of physical activity on sleep disturbance in seven older adults with mild cognitive impairment at a long-term care facility in the United States.

 

Feel the beat, not the burn: Study shows your favorite playlist can help you train harder and longer: New research from the University of Jyväskylä (JYU) shows that letting exercises choose their own music can boost endurance by nearly 20 % - without making the workout feel any tougher. The findings have practical benefits for both athletes and everyday exercisers. Participants who pedalled to their own self-selected tracks (around 120-140 beats per minute) lasted an average of nearly 6 minutes longer before reaching exhaustion compared to riding in silence. That’s the key finding from a new study now available online in the journal Psychology of Sport & Exercise. 

 

Lying Down For Ten Minutes A Day Can Improve Your Balance And Agility: The least athletic thing you can do turns out to be surprisingly good training. Lie flat on the floor, flex your knees, press your fingertips lightly into your abdomen, and contract against the pressure. Then, in a slow and deliberate sequence, tilt your pelvis, lift your hips slightly, and extend one leg while dorsiflexing the ankle. Do this for ten minutes. Repeat for two weeks. Researchers at Tokyo University of Agriculture and Technology have now shown that something close to this routine, performed entirely on your back, measurably improves how steadily you stand and how quickly you can change direction on your feet. The finding runs against the logic most of us apply to exercise: that balance is trained upright, in the positions that challenge it. But the study, published in PLOS ONE, suggests the body’s postural control system can be recalibrated from the floor up, in a position so biomechanically safe it barely qualifies as exertion. 

 

                                                     PREVENTION: Sleep

Tracking Your Sleep Could Backfire If You Have Insomnia: A recent study published in Frontiers in Psychology has found that sleep apps may be helpful to some people, but for those with insomnia, negative effects may be more likely.  The researchers also note that these sleep apps may not provide an accurate picture of your sleep and may actually make it more difficult for people to rest. 

 

Sleep Meds While Pregnant Don’t Raise Child’s Risk Of Psychiatric Disorder, Major Korean Study Finds: The research, published in The BMJ, followed 3.8 million children born between 2010 and 2022, tracking whether those whose mothers took sedative medications during pregnancy were more likely to develop psychiatric or neurodevelopmental conditions. ADHD, autism, schizophrenia, mood disorders, intellectual disability, behavioural disorder: twelve conditions in all, assessed over up to fourteen years of follow-up. The study provides meaningful reassurance, but it’s not a green light for unrestricted use. The stronger message is that untreated maternal anxiety and insomnia also carry risks, and clinicians should weigh both sides of the equation rather than defaulting to avoidance. Decisions about sedative use during pregnancy remain individual conversations, informed now by considerably stronger evidence than before. 

 

                                                         PREVENTION: Diet

Coffee May Alter Gut Microbiome to Reduce Stress (Yes, Even Decaf): New researchTrusted Source from APC Microbiome Ireland suggests that both caffeinated and decaffeinated coffee can improve mood and reduce stress by acting on the gut–brain axis. Decaf coffee was associated with improved learning and memory, while caffeinated coffee enhanced attention and reduced anxiety and inflammation.

 

This daily habit could lower dementia risk by 35%, scientists say: A huge long-term study found that drinking two to three cups of coffee a day was linked to a much lower risk of dementia, especially before age 75. Researchers say caffeine may help keep brain cells active while reducing inflammation and harmful plaque buildup associated with Alzheimer’s disease. But more coffee wasn’t better — the protective effect appeared to level off after moderate intake. JAMA 

 

Eating Avocado and Mango Daily May Improve Blood Pressure in Prediabetes: Eating one avocado and 1 cup of mango daily may help improve heart health in as little as 8 weeks, according to a recent study. Researchers at the Illinois Institute of Technology found that adults with prediabetes who followed this combination experienced improved blood vessel function and reductions in diastolic blood pressure.  Journal of the American Heart AssociationTrusted Source

 

Scientists reversed biological age in older adults with a 4-week diet change: A four-week diet change was enough to make some older adults appear biologically younger in a new University of Sydney study. Participants who reduced fat intake or shifted toward more plant-based protein showed improvements in key health biomarkers tied to aging. The strongest results came from a lower-fat, higher-carb diet, while people eating closer to their usual diets saw almost no change. Aging Cell

 

Eating eggs could cut Alzheimer’s risk by 27%: Researchers found that people 65 and older who eat eggs regularly have a significantly lower risk of developing Alzheimer’s disease, with daily or near-daily consumption linked to up to a 27% reduction. Even modest egg intake showed benefits, suggesting that small dietary changes could make a meaningful difference over time. The Journal of Nutrition 

 

Recurring UTIs? Should Cranberry Products Be Recommended? Cranberry products may help prevent recurrent uncomplicated UTIs, especially in women and children, by reducing symptomatic risk by 30%. Standardized formulations with at least 36 mg of proanthocyanidins daily are recommended for effectiveness. Medscape 

 

                      PREVENTION: Vitamins/Supplements

Vitamin D may help prevent diabetes, depending on your genes: The study, published in JAMA Network Open, found prediabetic adults with certain variations in the vitamin D receptor gene had a 19% lower risk of developing diabetes when taking a high daily dose of vitamin D.

 

Vitamin D boosts breast cancer treatment success by 79%: A daily vitamin D supplement may quietly supercharge chemotherapy. In a small study, women who took low doses alongside treatment were far more likely to see their cancer vanish than those who didn’t. Since vitamin D also supports immune function—and many patients are deficient—it could be playing a bigger role than expected. Scientists say this affordable approach deserves much deeper investigation. Nutrition and Cancer 

 

Doctors warn this popular vitamin may quietly disrupt cancer care: Many cancer patients turn to biotin supplements hoping to restore hair lost during treatment, but experts warn the popular vitamin may do more harm than good. While biotin is often marketed for stronger hair and nails, there’s little evidence it actually helps cancer-related hair loss—and it can dangerously interfere with lab tests. Doctors say the supplement can distort key blood markers, potentially masking cancer recurrence or delaying treatment decisions. JCO Oncology Practice 

 

Fish oil may be hurting your brain, new study finds: Fish oil has long been praised as brain-boosting, but new research suggests the story may be more complicated. Scientists found that in people with repeated mild head injuries, a key omega-3 fatty acid in fish oil—EPA—may actually interfere with the brain’s ability to repair itself. Instead of helping recovery, it appears to weaken blood vessel stability, disrupt healing signals, and even contribute to harmful protein buildup linked to cognitive decline. Cell Reports 

 

Scientists say a daily multivitamin may help slow aging: A daily multivitamin may help slow biological aging, according to researchers studying older adults in a large clinical trial. After two years, participants taking multivitamins showed slower aging in several DNA-based “epigenetic clocks,” with the effect equal to about four months less biological aging. People who started out biologically older than their actual age appeared to benefit the most. The findings hint that a simple supplement could play a role in healthier aging. Nature Medicine 

 

Nicotinamide Linked to Lower Melanoma Risk in Patients With Previous Skin Cancer: Nicotinamide supplementation may reduce melanoma risk by 33% in patients with previous skin cancers, according to a study of over 33,000 veterans. The effect was significant for invasive melanoma, suggesting potential for primary prevention. American Academy of Dermatology (AAD) 2026 Annual Meeting

 

 

                                                   PREVENTION: Other

Marriage Linked to Lower Cancer Risk, But Experts Say It Doesn’t Equal Prevention: A recent study published in the journal Cancer Research Communications suggests that being or having been married may be associated with reduced cancer risk. This means that, according to the data, many people may be missing out on the health benefits of marriage.  However, there are some who say that the societal concept of marriage being “better” than being single may skew data and the interpretations of it.

 

AHA identifies 10 key factors to lower dementia and stroke risk:  The American Heart Association (AHA) published a scientific statementTrusted Source outlining how experiences throughout a person’s life can affect brain health and how a person can improve their brain health. “The main takeaway is that brain health is not determined only by age or genetics. It is shaped across the entire lifespan by a combination of physical health, mental health, sleep, lifestyle, social support, environment, and access to care. The American Heart Association statement is important because it reframes brain health as something we can influence much earlier and more broadly than we used to think.”

 

Visiting A Museum Once A Week Slows Biological Aging As Much As Regular Exercise: A study published this week in Innovation in Aging provides the first evidence that arts and cultural engagement is linked to slower epigenetic ageing, with effects comparable in magnitude to those seen for physical exercise. The findings, from a UCL team led by Professor Daisy Fancourt, add a genuinely unexpected entry to the list of behaviours that seem to slow biological time. 

 

Patchouli Oil Lotion Matches DEET At Repelling Mosquitoes In Lab Tests: The rich, earthy aroma that makes patchouli so polarising in perfume also makes it, apparently, rather good at confusing mosquitoes. A team of researchers at Brazil’s Federal University of Amapá has managed to turn this botanical oddity into a lotion that performs as well as DEET, the synthetic repellent that has dominated bug sprays since the US military developed it in the 1940s. 

 

Daily routines may strengthen circadian rhythms and support healthy aging: A study suggests that middle-aged and older adults with stronger, more regular daily patterns of activity and rest showed signs of slower biological aging. Participants with clearer differences between daytime activity and nighttime rest, and less fragmented routines, had more ‘youthful’ physiological age scores.  The associations remained significant even after researchers accounted for factors including chronological age, sex, education, and certain health conditions.  The findings suggest that rest-activity rhythms could become targets for interventions, potentially using wearable devices or lifestyle changes, aimed at slowing the aging process.  JAMA Network OpenTrusted Source


Tattooing Linked to Lymphoma and Skin Cancer Risk: Tattooing may be linked to increased lymphoma and skin cancer risk, though causation isn't proven. Studies suggest tattoo size and ink composition could influence this association, but further research is needed to confirm these findings. Medscape 

 

 

                                                                  TREATMENT

Bariatric Surgery Linked to Higher Nutrient Deficiency Risk: Over 1 year, metabolic bariatric surgery (MBS) was associated with a higher risk for multiple micronutrient deficiencies than GLP-1 receptor agonist (GLP-1 RA) therapy. It was also linked to more than sixfold higher frequency of new vitamin B12 prescriptions, a higher risk for certain metabolic complications, and a lower risk for neuropathies than GLP-1 RA therapy.  Digestive Disease Week (DDW) 2026

 

Gastric Sleeve Endoscopy Helps Patients Maintain Weight Loss 1 Year After Stopping GLP-1s: Gastric sleeve endoscopy combined with lifestyle changes led to 17% weight loss at 12 months, outperforming lifestyle changes alone, which resulted in only 0.1% weight loss, in patients who stopped GLP-1 receptor agonists. Digestive Disease Week (DDW) 2026 

 

GLP-1 Drugs: Interaction Risks With Oral Medications? GLP-1 receptor agonists may alter absorption of oral medications due to delayed gastric emptying, affecting drug levels and efficacy. Notable interactions include oral contraceptives, levothyroxine, and dabigatran, necessitating careful monitoring and potential dose adjustments. Medscape 

 

How Limited Is Evidence for Preventing Nephrolithiasis (Kidney Stones)? A systematic review published in the Annals of Internal Medicine evaluated the effectiveness of interventions to prevent the recurrence of nephrolithiasis or kidney stones. Across 31 studies including more than 30,000 participants, researchers found pharmacologic strategies (thiazides and allopurinol) that may reduce the risk for new stones, along with dietary interventions showing favorable but limited effects. This review also raises caution regarding the use of lemon juice.

 

Recurring UTIs? Should Cranberry Products Be Recommended? Cranberry products may help prevent recurrent uncomplicated UTIs, especially in women and children, by reducing symptomatic risk by 30%. Standardized formulations with at least 36 mg of proanthocyanidins daily are recommended for effectiveness. Medscape 

 

New Breast Density Treatment May Have Fewer Side Effects, Lower Cancer Risk: A study has found promising results with the breast cancer prevention drug (Z)-endoxifen. The drug reduced breast density safely and with fewer side effects than tamoxifen. It also had fewer troublesome side effects than this standard preventive treatment. Experts say that if further research confirms these findings, the endoxifen could help increase compliance and improve outcomes. Journal of the National Cancer InstituteTrusted Source 

 

New Ozempic pill may offer more affordable alternative to injectables: Novo Nordisk announced its rebranded oral semaglutide pill, Rybelsus, will soon be available as the ‘Ozempic pill’ following a formulation change. The smaller, reformulated pill will be available in different dosages than the Rybelsus pill, with Novo Nordisk stating it provides the same efficacy and safety profile as the original formulation. The healthcare company also states that the Ozempic pill will be available nationwide through pharmacies, telehealth, and mail-order services.  Pricing is expected to vary by coverage, with insured patients potentially paying $25 for up to 3 months, while self-pay options are estimated between $149 and $299 per month depending on dose. Medical News Today

 

Treatment-resistant IBD may benefit from new combo antibody therapy: Two new studies recently presented at Digestive Disease Week® (DDW) 2026 report that a combination of two medications may offer better results in treating IBD than using each drug individually, especially in people where other therapies had previously failed.

 

Urine Test Cuts Unnecessary Prostate Biopsies By Nearly Two-Thirds In Head-To-Head Trial Against MRI: Every year, hundreds of thousands of men with low-grade prostate cancer face a recurring dilemma: submit to another biopsy, with its attendant discomfort and small but real infection risk, or hope that the cancer growing quietly inside them hasn’t quietly changed. The dilemma exists because the tools available to guide that decision have, until now, been frustratingly imprecise. MRI scans help. PSA blood tests help. But neither helps enough to let doctors say, with real confidence, that a biopsy can safely wait. A new study suggests a simple urine test could break that impasse. Evaluated across 11 urology practices in the United States, the test outperformed MRI on every meaningful metric, and in doing so raised a question that researchers are only beginning to take seriously: how many of the biopsies performed on men with low-risk prostate cancer are actually necessary? The answer, at least in this study, is roughly a third. Maybe fewer. 

 

Ozempic delivers major weight loss in adults over 65, study finds: A major new analysis suggests semaglutide (Ozempic, Wegovy) works remarkably well in adults over 65, helping many lose substantial amounts of weight while improving heart and metabolic health. Participants taking the drug lost over 15% of their body weight on average — far more than those receiving placebo treatment. Many also moved out of obesity categories entirely and reached healthier weight levels. European Association for the Study of Obesity 


Colon cancer breakthrough keeps patients cancer-free for nearly 3 years: A short burst of immunotherapy before surgery is delivering surprisingly powerful results for a specific type of colorectal cancer. Patients in a UK-led trial who received just nine weeks of pembrolizumab prior to surgery have remained cancer-free nearly three years later—an outcome that challenges the standard approach of surgery followed by months of chemotherapy. Science Daily

 

Pancreatic Cancer Vaccine Still Shows Promise 6 Years Out: A personalized mRNA vaccine for pancreatic cancer shows promise, with 87.5% of initial responders surviving after six years. This suggests potential for improved outcomes in one of the deadliest cancers.  American Association for Cancer Research (AACR) Annual Meeting 2026.

 

Postmenopausal HRT Tied to Glaucoma Risk in Women: In Finnish women aged 50 years or older, the use of any postmenopausal hormone replacement therapy (HRT) was linked to a higher risk for developing glaucoma, with estrogen-only therapy specifically associated with the risk for primary open-angle glaucoma.  published online on April 12, 2026, in Acta Ophthalmologica.

 

‘Too Good to Be True?’ GLP-1s and Breast Cancer Survival: A new study suggests that GLP-1 drugs like Ozempic might reduce the risk of death after a breast cancer diagnosis by 91%. this new study appearing in JAMA Network Open. Data quality issues and potential biases cast doubt on these findings.

 

Antidepressants During Pregnancy Not Linked to Autism, ADHD: A comprehensive review found no causal link between antidepressant use before or during pregnancy and ADHD or autism. Any association of neurodevelopmental disorders appears to be linked to genetic or environmental factors. While antidepressants do have potential risks, it’s important to weigh them against the benefits. Untreated depression is associated with serious risks to both the pregnant person and their baby. The Lancet PsychiatryTrusted Source 

 

Novel Parkinson’s Disease Drug May Delay Need for Levodopa: Tavapadon, a novel dopamine receptor agonist, may delay levodopa initiation in Parkinson's patients, with 90% avoiding levodopa after 20 months. However, experts urge caution in interpreting these promising results.  American Academy of Neurology (AAN) 2026 Annual Meeting.

 

 

                                                                              OTHER

Scientists Rethink How Much Lifespan Is in Our Control: A recent study published in Science found that lifespan is about 50% heritable — roughly double earlier estimates and on par with other complex traits like height and cognitive function. For clinicians, this reinterpretation could help ground patients consumed by the “kale and cardio” promise of extreme longevity.

 

FDA Blocks Publication of Vaccine Safety Studies. Why Experts Are Concerned: The Food and Drug Administration (FDA) has blocked the publication of COVID-19 and shingles vaccine safety studies, citing concerns over their conclusions. Experts question the decision to withdraw the studies, since both vaccines have substantial evidence supporting their safety and effectiveness. Some experts say the decision may be influenced by HHS Health Secretary Robert F. Kennedy Jr.’s anti-vaccine agenda. Healthline 

 

Fluoride in Drinking Water Has No Effect on IQ or Brain Function, Study Finds: The research, published on April 13 in the Proceedings of the National Academy of Sciences (PNAS), reports that there appears to be no difference at any stage of life between people who grow up with water fluoridation and those who do not. “We find no evidence that [community water fluoridation] is negatively associated with adolescent IQ or adult cognitive functioning,” the study authors wrote. The findings are in contrast to Health and Human Services (HHS) Secretary Robert F. Kennedy’s announcement in April that he would require the Centers for Disease Control and Prevention (CDC) to revise its long-standing recommendationTrusted Source that fluoride be added to drinking water.

 

This simple strength test could predict how long you live: Staying strong may be one of the biggest secrets to living longer — especially for older women. A major study of more than 5,000 women found that simple signs of muscle strength, like a firm hand grip or the ability to quickly stand up from a chair, were strongly linked to lower risk of death over the next eight years. JAMA Network Open

 

Early-Onset Colorectal Cancer Risk Factors Identified in Two Studies: Two new studies have identified risk factors that may be associated with the increasing incidence of colorectal cancer (CRC) among younger Americans. In the first study, Eldesouki and colleagues identified a distinct phenotype, based on multiple factors, associated with an elevated risk in people aged 18-49 years. In addition, they found that inflammatory bowel disease, family history of CRC, severe obesity, and obesity were independent predictors that increased the risk for early-onset vs late-onset CRC more than twofold. In the second study, a history of oral antibiotic exposure was associated with an increased risk for colorectal adenomas, especially among people with a greater or longer history of using these agents. Digestive Disease Week (DDW) 2026.

 

The Supreme Court keeps abortion pill mifepristone available by telehealth: The Supreme Court decided to keep the status quo in place for medication abortion access Thursday.  The high court's order means the abortion pill mifepristone will remain available via telehealth as a case brought by Louisiana against the Food and Drug Administration proceeds through the lower courts. NPR

 

Hantavirus Arrives in U.S.: Could Cruise Ship Outbreak Cause Next Pandemic? 18 American passengers have been airlifted home to the U.S. after a deadly hantavirus outbreak aboard an Antarctic expedition cruise ship. Investigators believe the rare Andes virus strain may have spread among passengers in the ship’s close quarters. Experts say the outbreak highlights the severity of hantavirus, but stress that the broader risk of a COVID-like pandemic remains low. Healthline 

 

Biologic Evidence May Reshape Long-COVID Diagnosis and Care: Biologic evidence suggests long COVID has a biological basis, not psychosomatic, affecting over 1.5 million in Germany by 2024. Effective management requires distinguishing postexertional malaise from fatigue and adopting symptom-oriented treatment strategies. 132nd Congress of the German Society for Internal Medicine