Sunday, July 19, 2020

Journal Watch July 2020


COVID
We’re Nowhere Near Herd Immunity with COVID-19, Experts Say: Experts say we’re nowhere close to achieving herd immunity against COVID-19 in the United States. In addition, a new study suggests that antibodies developed during an infection may only last for a few months. Experts say personal behaviors, such as wearing masks, washing hands, and physical distancing, are the best ways to stop the spread of COVID-19. Healthline

CDC Updated List of Those with Higher Covid Risks: The Centers for Disease Control and Prevention (CDC) has updated its listTrusted Source of underlying conditions that may lead to more severe outcomes from a COVID-19 diagnosis. CDC now warns that among adults, risk increases steadily as you age, and it’s not just those over the age of 65 who are at increased risk for severe illness. Other conditions include: Chronic kidney disease; COPD (chronic obstructive pulmonary disease); Obesity (BMI of 30 or higher); Immunocompromised state (weakened immune system) from solid organ transplant; Serious heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies Sickle cell disease Type 2 diabetes

Repurposing MMR vaccine for COVID-19 New research shows that the common vaccine that protects against measles, mumps, and rubella (MMR) could help prevent inflammation in COVID-19, which leads to severe symptoms. mBio

Common heartburn drugs may be tied to higher COVID risk: Popular heartburn medications such as Prilosec (omeprazole) and Nexium (esomeprazole) may inadvertently up your chances of catching COVID-19, new research suggests. An online survey of more than 53,000 Americans found that those taking a PPI once a day saw their risk for contracting COVID double. Those taking a PPI twice a day saw their COVID infection risk nearly quadruple. The American Journal of Gastroenterology

One in three young adults may face severe COVID-19, study shows: As the number of young adults infected with the coronavirus surges throughout the nation, a new study by researchers at UCSF Benioff Children's Hospitals indicates that youth may not shield people from serious disease. The impact of smoking surpassed other less common risks, the UCSF researchers reported in their study, which publishes in the Journal of Adolescent Health

Asthma does not seem to increase the severity of COVID-19: “People with asthma -- even those with diminished lung function who are being treated to manage asthmatic inflammation -- seem to be no worse affected by SARS-CoV-2 than a non-asthmatic person. There is limited data as to why this is the case -- if it is physiological or a result of the treatment to manage the inflammation." Journal of Allergy and Clinical Immunology

Physical distancing interventions cut incidence of COVID-19: Physical distancing interventions are associated with a reduced incidence of COVID-19 globally, according to a study published online July 15 in The BMJ.
   
COVID-19: Considering meditation and yoga as adjunctive treatment: The anti-inflammatory and other beneficial effects of meditation and yoga practices make them potential adjunctive treatments of COVID-19, according to the peer-reviewed journal JACM, The Journal of Alternative and Complementary Medicine. Click here to read the article.

Lopinavir/Ritonavir COVID-19 Treatment Linked to Bradycardia: Lopinavir/ritonavir (LPV/RTV) treatment of COVID-19 is associated with an increased risk for bradycardia. Patients with bradycardia were older, had increased RTV concentration at 72 hours, lower lymphocytes. July 9 in Circulation: Arrhythmia and Electrophysiology.

Variety of Symptoms Reported for COVID-19 Patients: Nearly all symptomatic COVID-19 patients experience fever, cough, or shortness of breath, and a wide variety of other symptoms are reported, according to research published July 17 in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. Gastrointestinal symptoms and other symptoms (such as chills, myalgia, headache, and fatigue) were also commonly reported.

COVID-19-Related Symptoms Persist After Recovery: Most patients who have recovered from COVID-19 report persistence of at least one symptom, according to a research letter published online July 9 in the Journal of the American Medical Association.

Even People With Lung Disease Should Wear Masks: Experts: People with chronic lung disease may worry about being able to breathe freely with face masks, but they should wear the coverings if possible, four leading medical groups say. "Individuals with normal lungs and even many individuals with underlying chronic lung disease should be able to wear a non-N95 facial covering without affecting their oxygen or carbon dioxide levels," the American College of Chest Physicians, the American Lung Association, the American Thoracic Society and the COPD Foundation said in a statement released Thursday. The groups acknowledged that some people with lung diseases might not be able to tolerate breathing with a mask and will seek a mask exemption from their doctor.

K-State study first to show SARS-CoV-2 is not transmitted by mosquitoes: A new study by Kansas State University researchers is the first to confirm that SARS-CoV-2 cannot be transmitted to people by mosquitoes.
No Big Increase Seen in Loneliness During U.S. COVID-19 Outbreak: Social distancing during the COVID-19 pandemic has not led to an overall increase in loneliness among Americans, according to a study published online June 22 in American Psychologist.

PAIN
New Drug Combo May Help Ease Fatigue Caused by Rheumatoid Arthritis: In a 2-year study, the drugs methotrexate and prednisone were effective in reducing the fatigue of participants who took them. Experts say relieving the unrelenting fatigue allows people with rheumatoid arthritis to live more pain-free and productive lives. 2020 conference of the European E-Congress of Rheumatology

Low Back Pain Also May Resolve in Some After Hip Replacement: Symptomatic low back pain (LBP) resolves in 82 percent of patients with hip and back pain who undergo total hip arthroplasty (THA), according to a study presented at the American Academy of Orthopaedic Surgeons 2020 Virtual Education Experience. 
Physically Demanding Jobs May Raise Risk for Knee Osteoarthritis: Occupational lifting, kneeling, climbing, squatting, standing versus sedentary work linked to knee OA. Arthritis Care & Research

Tanezumab Improves Pain, Function in Chronic Low Back Pain: Low back pain intensity at week 16 was improved with tanezumab 10 mg versus placebo. PAIN

Significantly less addictive opioid may slow progression of osteoarthritis while easing pain: A novel preclinical study by Keck Medicine of USC researchers, published in Arthritis & Rheumatology, reveals that a potential new opioid medication may have the ability to slow the progression of osteoarthritis while being less addictive than commonly prescribed opioid drugs.

A furrysocial robot can reduce pain and increase happiness: Researchers have discovered that a single, 60-minute interaction with PARO actually improved mood as well as reduced mild or severe pain. When participants touched PARO, they experienced greater pain reduction than when it was simply present in their room. Scientific Reports

COMPLEMENTARY & ALTERNATIVE MEDICINE
Medical pot mayhelp many battle insomnia, pain and stress: In a survey of nearly 1,300 people with chronic health conditions, researchers found that those using "medicinal cannabis" reported less pain, better sleep and reduced anxiety. They also tended to use fewer prescription medications and were less likely to have been to the hospital recently. The results do not prove, however, that medicinal cannabis is effective. It's also unclear whether certain products were linked to particular benefits. Cannabis and Cannabinoid Research

Factors maximize impact of yoga, physical therapy on back pain in underservedpopulation: New research shows that people with chronic low back pain (cLBP) have better results from yoga and physical therapy compared to reading evidence-based self-help materials. While this finding was consistent across many patient characteristics, a much larger effect was observed among those already taking pain medication to treat their condition and those who did not fear that exercise would make their back pain worse. Led by researchers at Boston Medical Center and published in Pain Medicine, the findings also showed that individuals who expected to do well with yoga were more likely to have a meaningful improvement in their function if they received yoga compared to receiving physical therapy. 

Meditation linked to lower cardiovascular risk: Meditation was linked to lower cardiovascular risk in a data analysis by Veterans Affairs researchers and colleagues. American Journal of Cardiology.

Cannabis shows potential for mitigating sickle cell disease pain: Cannabis appears to be a safe and potentially effective treatment for the chronic pain that afflicts people with sickle cell disease, according to a new clinical trial. JAMA Network Open.

FDA ACTION
• Approved Inqovi (decitabine and cedazuridine) tablets, an oral outpatient treatment option for patients with myelodysplastic syndromes and chronic myelomonocytic leukemia
• Approved a new type of antiretroviral medication, Rukobia (fostemsavir), for people with HIV who have not had success with other therapies
• Approved Phesgo to be given to a patient at home by a health care professional after completing chemotherapy for breast cancer treatment


PREVENTION: Exercise
Stretching your legs may help prevent diseases such as heart diseases and diabetes: New research in the Journal of Physiology shows that 12 weeks of easy-to-administer passive stretching helps improve blood flow by making it easier for your arteries to dilate and decreasing their stiffness. Passive stretching differs from active stretching in that the former involves an external force (another person or gravity) stretching you, whereas active stretching is performed on your own.

Mortality risk down with meeting recommended exercise levels: The risk of all-cause and cause-specific mortality is reduced for adults who engage in leisure time aerobic and muscle strengthening activities at levels recommended by the 2018 physical activity guidelines, according to a study published online July 1 in The BMJ. 

Study links increased exercise with lower sleep apnea risk: A study published online as an accepted paper in the Journal of Clinical Sleep Medicine found that increased physical activity is associated with a lower risk of obstructive sleep apnea, a common sleep-related breathing disorder. The study is the largest to date focused on the relationship between sleep apnea and levels of physical activity in the general community.
   
PREVENTION: Diet/Nutrition
A Small Amount of Fruits, Whole Grains Every Day Can Slash Type 2 Diabetes Risk: Two studies show that a modest increase in fruits, vegetables, and whole grains can reduce the risk of developing type 2 diabetes. One studyTrusted Source, dealing with whole grains intake, was conducted by researchers in the United States. The other studyTrusted Source, which analyzed fruits and vegetables, was authored by a team of European researchers. That increase can be as simple as consuming one or more servings a day of whole grain breakfast cereal or slightly increasing fruit and vegetable intake. The whole grains study found that those who consumed two or more servings of oatmeal per week had a 21 percent lower risk than those who had less than one serving per week.

Raw milk may harbor antibiotic-resistant germs: Analysis of raw milk samples bought in the United States found small numbers of beneficial bacteria alongside potentially dangerous antibiotic-resistant bacteria, which increased in number when left at room temperature. The findings, published in the journal Microbiome, suggest that raw milk could lead to the spread of antibiotic resistance, particularly if the product is not appropriately chilled.

Not All Food Sources of Fructose-Containing Sugars Raise Risk for MetS: The adverse association of sugar-sweetened beverages and incident metabolic syndrome (MetS) does not extend to other major food sources of fructose-containing sugars, and yogurt, fruit, 100 percent fruit juice, and mixed fruit juice all have a protective association with MetS, according to a review published online July 9 in JAMA Network Open.

 Plant Protein Intake Linked to Drop in Overall, CVD Mortality: Higher plant protein intake is associated with reductions in the risks for overall and cardiovascular disease mortality in men and women, according to a study published online July 13 in JAMA Internal Medicine.

Soy and wheat proteins helpful for building aging muscles, but not as potent as animal protein: On a gram for gram basis, animal proteins are more effective than plant proteins in supporting the maintenance of skeletal muscle mass with advancing age, shows research presented this week at The Physiological Society's virtual early career conference Future Physiology 2020.
   
PREVENTION: Supplements
Probiotics may reduce symptoms of depression: A new review has found that probiotics, or a combination of prebiotics and probiotics, may help reduce the symptoms of depression. However, the review found that prebiotics and probiotics did not have a statistically significant effect on anxiety. Also, prebiotics on their own did not significantly reduce anxiety or depression symptoms. BMJ Nutrition, Prevention & Health

Supplements with potential to prevent Alzheimer's affect blood, but less so the brain: In the first Alzheimer's prevention study to compare levels of omega-3s in the blood with those in the central nervous system, findings suggest that higher doses of omega-3 supplements may be needed in order to make a difference, because dramatic increases in blood levels of omega-3s are accompanied by far smaller increases within the brain. Among participants who carry a specific mutation that heightens risk for Alzheimer's, taking the supplements raised levels of a key fatty acid far less compared to those without the mutation. EBioMedicine


PREVENTION
Experts strongly recommend varenicline over the patch for adult smokers hoping to quit: Smoking cessation initiatives notwithstanding, along with provocative public health campaigns and clinical guidance, quitting tobacco has remained elusive for many smokers. The American Thoracic Society's new clinical practice guideline on treatment for tobacco dependence in adults addresses how clinicians may deal with patients' reluctance to quit, one of a number of issues not previously assessed in the older guidelines. American Journal of Respiratory and Critical Care Medicine

Flu Vaccine Cuts Cardiovascular Mortality in Adults With Diabetes: Vaccination was significantly associated with reduced risks for all-cause death, cardiovascular death and death from AMI or stroke. Vaccination was also associated with a reduced risk for being admitted to the hospital with acute complications associated with diabetes, like diabetic ketoacidosis, hypoglycemia, or coma. Diabetes Care

 

TREATMENT
Medical management alone better for brain AV malformations: Among patients with unruptured brain arteriovenous malformation, medical management alone is superior to its combination with interventional therapy for prevention of death or symptomatic stroke in the long term, according to a study published in the July 1 issue of The Lancet Neurology.

Risk for Heart Failure Increased for Women Taking β-Blockers: Women taking β-blockers for hypertension have an increased risk for developing heart failure when they present to the hospital with acute coronary syndrome, according to a study published online July 10 in Hypertension.
   
Baloxavir prevents spread of flu to household members: The antiviral drug baloxavir (Xofluza) prevented influenza in household contacts of infected patients, according to a study in the New England Journal of Medicine

Ticagrelor-aspirin beneficial for mild-to-moderate stroke, TIA: Ticagrelor-aspirin is associated with a reduced risk for the composite of stroke or death within 30 days of mild-to-moderate acute noncardioembolic ischemic stroke or transient ischemic attack (TIA), according to a study published in the July 16 issue of the New England Journal of Medicine.

Roflumilast Cream Promising for Chronic Plaque Psoriasis: Roflumilast cream is superior to placebo vehicle cream for reducing psoriasis severity, according to a study published in the July 16 issue of the New England Journal of Medicine.

High-fatdiet with antibiotic use linked to gut inflammation: Combining Western diet and antibiotic use is a pre- IBS (irritable bowel syndrome) risk factor. Cell Host & Microbe

World-first technology breathes new life into cystic fibrosis detection and treatment:  World-first research, led by Monash University, has developed radical non-invasive X-ray technology aimed at helping diagnose, treat and manage people with cystic fibrosis. The technology can pinpoint localised areas of deficiency in a lung, offering potential for faster and more accurate diagnoses. Researchers can track the movement of air through the lungs, improving their capacity to assess lung function in both healthy and diseased lungs. Scientific Reports

New guideline: Don't routinely screen for EAC in patients with chronic GERD: A new guideline from the Canadian Task Force on Preventive Health Care, based on a rigorous systematic review of the latest evidence, found no benefit of routine screening for esophageal adenocarcinoma (EAC) and precursor conditions (Barrett esophagus and dysplasia) in patients with chronic gastroesophageal reflux disease (GERD). The guideline, published in CMAJ (Canadian Medical Association Journal), recommends physicians in Canada continue current practice to not screen routinely

Medication Use Linked to Weight Gain in Postmenopausal Women: For postmenopausal women, antidepressants, beta-blockers, and insulin are associated with weight gain over three years, according to a study published online July 15 in Menopause.

OTHER
Surgery in older adults does not up risk for Alzheimer disease: Older adults who have surgery with general anesthesia may experience a modest cortical thinning in the brain, but it does not appear to be tied to Alzheimer disease, according to a study recently published in the British Journal of Anaesthesia.

Electronic Health Records Fail to Detect Many Medication Errors: Though broadly used in U.S. hospitals, EHRs fail to detect up to one-third of medication errors JAMA Network Open

Many OlderAmericans Face Ageism Every Day, Survey Finds: A new poll finds that most older adults encounter at least one form of this "everyday ageism" in their day-to-day lives and that more frequent encounters may affect their health and well-being.

 

 



 





 



 

 

 


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